Stabilisierung von Interleukin-6 in serumbasierten Lösungen

Details

Veröffentlichungs-Nr.

EP2415461

Aktenzeichen

EP10007718

Anmeldetag

24. Juli 2010

Veröffentlichung

31. Oktober 2012

Erteilung

31. Oktober 2012

Rechtsraum

EP

IPC

A61K9/08A61K9/19A61K38/20A61K47/18A61K9/00

Abstract

In one aspect, the invention is directed to a composition comprising IL-6, an isoform or a fragment thereof, a compound of the formula C 10 - C 18 -Alkyl trimethylamonium halogenide (1), wherein the compound is saturated or unsaturated and / or substituted or non substituted, or a salt thereof, wherein the concentration of the compound in the composition is about 0.15 - about 0.4%, and a serum. The present invention is further directed to a kit comprising a composition or a lyophilisate and an instruction for use. A further embodiment of the present invention is method of stabilizing IL-6, an isoform or a fragment thereof, comprising the steps of mixing IL-6, an isoform or a fragment thereof, a compound of the formula C 10 - C 18 -Alkyl trimethylamonium halogenide (I), wherein the compound is saturated or unsaturated and / or substituted or non substituted, or a salt thereof, wherein the concentration of the compound in the composition is about 0.15 - about 0.4%, and a serum.

Anmelder

Firmen

Roche Diagnostics GmbH
F. Hoffmann-La Roche AG

Land

🇩🇪 Deutschland

Fachgebiete