6-(4-Hydroxy-Phenyl)-3-Styryl-1H-PYRAZOLO[3,4-B]pyridin-4-Carbonsäureamid-Derivate als Kinaseinhibitoren

Details

Veröffentlichungs-Nr.

EP2567959

Aktenzeichen

EP11306130

Anmeldetag

12. September 2011

Veröffentlichung

13. März 2013

Erteilung

16. April 2014

Rechtsraum

EP

IPC

(IRM LLC et al.)(VERTEX PHARMA et al.)

Abstract

The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula, in which R 1 , R 2 , R 3 , R 4 and R 5 are defined as indicated below. The compounds of the formula are kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Anmelder

Firma

SANOFI

Land

🇫🇷 Frankreich

Fachgebiete