Pseudotypisierung von schaumigen Viren

Details

Veröffentlichungs-Nr.

EP2583974

Aktenzeichen

EP11186173

Anmeldetag

21. Oktober 2011

Veröffentlichung

26. April 2017

Erteilung

26. April 2017

Rechtsraum

EP

IPC

C07K14/15C12N7/02C12N15/867

Abstract

The present invention relates to means and methods for pseudotyping of foamy viruses and the pharmaceutical application of pseudotyped foamy virus particles. The invention is applicable in biomedical research and in diagnostic and therapeutic applications. One aspect of the invention is a fusion protein comprising a foamy virus capsid (Gag) protein and a first dimerization domain that is applicable to dimerize with a second dimerization domain from another protein upon binding of a small molecule ligand to both the first and the second dimerization domain. Another aspect of the invention is a fusion protein comprising an envelope (Env) protein not derived from foamy virus and a second dimerization domain that is applicable to dimerize with a first dimerization domain from another protein upon binding of a small molecule ligand to both the first and the second dimerization domain. Another aspect of the invention is a fusion protein comprising a membrane-targeting domain not derived from foamy virus, and a second dimerization domain that is applicable to dimerize with a first dimerization domain from another protein upon binding of a small molecule ligand to both the first and the second dimerization domain.

Anmelder

Firma

Technische Universität Dresden

Land

🇩🇪 Deutschland

Fachgebiete