Polypeptide mit hoher MAST2-Affinität und deren Verwendungen

Details

Veröffentlichungs-Nr.

EP2592091

Aktenzeichen

EP11306454

Anmeldetag

8. November 2011

Veröffentlichung

20. September 2017

Erteilung

20. September 2017

Rechtsraum

EP

IPC

C07K14/435

Abstract

The invention relates to polypeptides containing a cytoplasmic domain ending with a MAST-2 binding domain, from 11 to 13 residues, the first two residues of which are S and W, and the last four residues of which are Q, T, R and L, said polypeptides presenting a high affinity for the PDZ domain of the human MAST2 protein. The invention also relates to polynucleotides, vectors, lentiviral particles, cells as well as compositions comprising the same. The invention is also directed to the use of said polypeptides, polynucleotides, vectors, lentiviral particles, cells and compositions in the treatment and/or prevention of a disease, disorder or condition, which alters the Central Nervous System (CNS) and/or the Peripheral Nervous System (PNS). The invention also concerns molecular signatures of cellular genes to determine the neurosurvival and/or neuroprotection activity of a molecule.

Anmelder

Firmen

Institut Pasteur
Centre National de la Recherche Scientifique
Université Pierre et Marie Curie (Paris 6)
UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)

Land

🇫🇷 Frankreich

Fachgebiete