Verfahren für In-vivo-Targeting von Nanopartikeln über bioorthogonale kupferfreie Click-Chemie
Anmelder: Korea Institute of Science and Technology 🇰🇷
Details
- Veröffentlichungs-Nr.
- EP2641616
- Aktenzeichen
- EP13159949
- Anmeldetag
- 19. März 2013
- Veröffentlichung
- 13. Dezember 2017
- Erteilung
- 13. Dezember 2017
- Rechtsraum
- EP
- IPC
- A61K47/69// A61K49/00
Abstract
The present disclosure relates to a method for in vivo targeting of a nanoparticle via bioorthogonal copper-free click chemistry, more particularly to a method for in vivo targeting of a nanoparticle, including: injecting a precursor capable of being metabolically engineered in vivo when injected into a living system and having a first bioorthogonal functional group into the living system; and injecting a nanoparticle having a second bioorthogonal functional group which can perform a bioorthogonal copper-free click reaction with the first bioorthogonal functional group attached thereto into the living system. In accordance with the present disclosure, accumulation of nanoparticles at a target site in a living system can be increased remarkably and the biodistribution of the nanoparticles can be controlled since the nanoparticles bound to a cell surface are taken up into the cell with time.
Anmelder
- Firma
- Korea Institute of Science and Technology
- Land
- 🇰🇷 Südkorea
Südkoreanisches staatliches Forschungsinstitut mit Sitz in Seoul, das interdisziplinäre Forschung in Naturwissenschaften, Ingenieurwesen und Materialtechnologie betreibt und zahlreiche Patente aus seinen Instituten hervorbringt.
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