Verfahren zur Diagnose von Osteochondrose

Details

Veröffentlichungs-Nr.

EP2719769

Aktenzeichen

EP12187726

Anmeldetag

9. Oktober 2012

Veröffentlichung

13. Juli 2016

Erteilung

13. Juli 2016

Rechtsraum

EP

IPC

C12Q1/68

Abstract

The invention provides an in vitro method or assay for the diagnosis of osteochondrosis or prediction of the likelihood of its onset in a terrestrian mammal, comprising measuring the expression level of a marker in a sample obtained from said terrestrian mammal with an agent that can be used to determine the expression level of said marker, and comparing the expression level measured in step a) to the expression level of said marker measured in a sample obtained from one or more terrestrian mammals of the same species not affected by osteochondrosis, wherein the marker is ApoB-3G, and wherein an increase in the expression level of ApoB-3G is indicative of osteochondrosis. Methods are provided for the diagnosis and/or prediction whether the fetlock joint, the hock joint or the stifle joint is or will be affected by osteochondrosis. The invention also provides a diagnostic kit for use in said method, which comprises at least one agent, which binds specifically to the product of the gene of the respective marker and which can be used to determine the expression level of said marker, wherein the marker is ApoB-3G.

Anmelder

Firmen

Université de Liège
Skuldtech S.A.

Land

🇧🇪 Belgien

Fachgebiete