Stabiles kristallines Monohydrat aus Epirubicinhydrochlorid und Herstellungsverfahren

Details

Veröffentlichungs-Nr.

EP2778172

Aktenzeichen

EP14159462

Anmeldetag

13. März 2014

Veröffentlichung

1. Februar 2017

Erteilung

1. Februar 2017

Rechtsraum

EP

IPC

C07H1/00C07H15/252

Abstract

The present invention relates to a stable crystalline monohydrate of epirubicin hydrochloride having water content in the range between 2.7% and 3.5% (w/w) and being devoid of residual solvents as well as to a corresponding method for its production. The method comprises: (a) adding at least a first solvent and at least a second solvent to epirubicin hydrochloride, wherein the first solvent is a linear or branched C 4 to C 5 alcohol, and the second solvent is a linear or branched C 2 to C 3 alcohol; (b) adjusting in the solution obtained the water content to an amount in the range between 7% and 12% (w/w); and (c) heating the mixture to a temperature of 70°C to 90°C in order to allow crystallization.

Anmelder

Firmen

Synbias Pharma AG
Synbias Pharma Ltd.

Land

🇨🇭 Schweiz

Fachgebiete