Stabile feste Formen von Regadenoson

Details

Veröffentlichungs-Nr.

EP2789624

Aktenzeichen

EP13163400

Anmeldetag

11. April 2013

Veröffentlichung

23. September 2020

Erteilung

23. September 2020

Rechtsraum

EP

IPC

C07H19/16C07H19/167

Abstract

A process for the preparation of the amorphous form of Regadenoson of formula <img class="EMIRef" id="468993210-ia01" /> is disclosed together with new crystalline polymorphic forms E, F and G and methods for their preparation. Regadenoson amorphous form can be prepared in mild reaction conditions with high chemical purity (>99.6%) and high stability to the heating. A particularly thermodynamically stable anhydrous crystalline form of Regadenoson (form G) is also disclosed, provided with high stability not when exposed to 90% RH at 25°C for 96 hour, but also to the heating up to 200°C.

Anmelder

Firmen

AMRI Italy S.r.l.
Euticals S.P.A.

Land

🇮🇹 Italien

Fachgebiete