Injektor mit Steuerbarer Probenverdünnung für ein Flüssigkeitschromatografiesystem

Details

Veröffentlichungs-Nr.

EP2993471

Aktenzeichen

EP15183268

Anmeldetag

1. September 2015

Veröffentlichung

15. November 2023

Erteilung

15. November 2023

Rechtsraum

EP

IPC

G01N30/06G01N30/20// G01N30/24

Abstract

A method, a device, and a computer program product for injecting a sample into a flow of a liquid chromatography system. A flow of a sample and a flow of a mobile phase are combined to create a diluted sample in the system flow. The volumetric flow rate of the sample and the volumetric flow rate of the mobile phase are controlled to be at a value that yields a desired dilution ratio for the diluted sample. The device includes a syringe (44) and a sample needle (48) to dispense a sample, a first fluid channel to conduct a mobile phase, a valve (42) comprising a first port (46A) in communication with said first fluid channel, a second port (46B) in communication with said syringe (44) via said sample needle (48), and a third port (46C). A control module (56) is in communication with said syringe (48) to control a volumetric flow rate of the sample dispensed from the syringe. Said control module (56) is in further communication with said valve (42) to thereby control the state of operation of the valve, wherein the mobile phase conducted through said first fluid channel is dispensed from the third port (46C) when the valve is in the first state and wherein the volumetric flow rate of the sample is controlled to a value to obtain a predetermined sample dilution ratio of a diluted sample dispensed from the third port (46C) when the valve is in the second state.

Anmelder

Firma

Waters Technologies Corporation

Land

🇺🇸 USA

Fachgebiete