Verfahren zur Synthese von Sulfonen und Sulfonamiden

Details

Veröffentlichungs-Nr.

EP3178811

Aktenzeichen

EP15306966

Anmeldetag

9. Dezember 2015

Veröffentlichung

31. Oktober 2018

Erteilung

31. Oktober 2018

Rechtsraum

EP

IPC

C07D213/71C07C315/04C07D265/30

Abstract

The present invention relates to a one pot single step process for the synthesis of a compound containing a sulfonyl functional group, in particular a sulfone or a sulfonamide, comprising the step of mixing together a silane, an SO 2 source, an electrophilic compound, an activating compound and optionally a metal catalyst. Labeled compounds containing a sulfonyl functional group, in particular labeled sulfones or sulfonamides can also be synthesized by the process of the invention. The present invention also concerns the use of unlabeled or labeled sulfonyl containing compounds, in particular labeled or unlabeled sulfones and sulfonamides, obtained by a process according to the invention in the manufacture of vitamins, pharmaceuticals, adhesives, acrylic fibers and synthetic leathers, pesticides, and fertilizers, for example. The present invention further relates to a process for producing tracers and tracers comprising a step of synthesis of a labeled sulfonyl containing compounds, in particular labeled sulfones and sulfonamides, obtained by a process according to the invention.

Anmelder

Firma

COMMISSARIAT À L'ÉNERGIE ATOMIQUE ET AUX ÉNERGIES ALTERNATIVES

Land

🇫🇷 Frankreich

Fachgebiete