Magnetisches Messsystem auf Basis eines Hochempfindlichen Planaren Hall Magnetoresistiven Biosensors (phr) und Verfahren zur Messung Niedriger Spezifischer Biopartikelkonzentrationen und zur Quantifizierung von Biopartikelinteraktionen

Details

Veröffentlichungs-Nr.

EP3252461

Aktenzeichen

EP16305639

Anmeldetag

2. Juni 2016

Veröffentlichung

26. Mai 2021

Erteilung

26. Mai 2021

Rechtsraum

EP

IPC

G01N27/74G01N33/543

Abstract

A magnetic measurement system (2) for measuring a concentration of specific bio-particles through a sensitive detection of magnetic particle labels comprises an aptamer-based magnetic hybrid AMR/PHR sensor (12) having an active surface (22) on which at least one magnetic particle (28) is ready to be or is closely bound through a sandwich-type aptamer structure that includes a captured unitary bio-particle. The magnetic measurement system is characterized in that an actual amplitude of an applied DC constant magnetic field onto the magnetic track (24) of the sensor (12) is closely located in a vicinity of an optimum amplitude of the permanent DC magnetic field comprised in a set of two optimum values H1, H2 of the permanent DC magnetic field, each optimum value H1, H2 maximizing locally the absolute value of a first quantity H ⋅ ∂ V MR ∂ H , <img class="EMIRef" id="487573866-ia01" /> where H is the amplitude of the applied magnetic field and ∂ V MR ∂ H <img class="EMIRef" id="487573866-ia02" /> is the derivate of the differential voltage with respect to the magnetic field at the applied field H.

Anmelder

Firmen

UNIVERSITE DE MONTPELLIER
Centre National de la Recherche Scientifique
Daegu Gyeongbuk Institute of Science and Technology
Ecole Nationale Supérieure de Chimie de Montpellier

Land

🇫🇷 Frankreich

Fachgebiete