Demenzmodell-Transgenmaus und Screening-Verfahren damit
Anmelder: Korea Institute of Science and Technology 🇰🇷
Details
- Veröffentlichungs-Nr.
- EP3305070
- Aktenzeichen
- EP17195792
- Anmeldetag
- 10. Oktober 2017
- Veröffentlichung
- 22. Juli 2020
- Erteilung
- 22. Juli 2020
- Rechtsraum
- EP
- IPC
- A01K67/027C12N15/85G01N33/50C12N5/073G01N33/68
Abstract
The present invention relates to a vector pair for screening tau oligomer formation, a mouse embryo introduced with the vector pair, a transgenic model mouse of neurological disease, obtained from the mouse embryo, and a method of screening a tau oligomer formation inhibitor candidate using the transgenic model mouse. More specifically, the present invention provides vector pair for screening tau oligomer formation, comprising: a first vector comprising a first tau gene, a first fluorescence protein gene and a first neuron-specific promoter; and a second vector comprising a second tau gene, a second fluorescence protein gene and a second neuron-specific promoter, wherein a protein expressed from the first fluorescence protein gene and a protein expressed from the second fluorescence protein gene bind to each other to display fluorescence, by association between a protein expressed from the first tau gene and a protein expressed from the second tau gene.
Anmelder
- Firma
- Korea Institute of Science and Technology
- Land
- 🇰🇷 Südkorea
Südkoreanisches staatliches Forschungsinstitut mit Sitz in Seoul, das interdisziplinäre Forschung in Naturwissenschaften, Ingenieurwesen und Materialtechnologie betreibt und zahlreiche Patente aus seinen Instituten hervorbringt.
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