Zusammengesetzter Blutgefässersatz und Verfahren zur Herstellung davon

Details

Veröffentlichungs-Nr.

EP3434292

Aktenzeichen

EP18185629

Anmeldetag

25. Juli 2018

Veröffentlichung

23. August 2023

Erteilung

23. August 2023

Rechtsraum

EP

IPC

A61L27/24A61L27/48A61L27/50A61L27/58

Abstract

The present invention relates to a composite vascular substitute, in particular for flow rates under 100 ml/min and inner diameters under 6 mm, which contains a non-resorbable knitted fabric layer (2), which is provided on the inner and outer sides with a collagen compound coating of freshwater fish - Czech carp. The non-resorbable knitted fabric compound (2) is preferably placed on a self-supporting resorbable collagen compound layer (1), wherein the non-resorbable layer (2) is covered with an intermediate collagen compound layer (4) overlaid with an outer, resorbable collagen compound layer (3). Furthermore, it relates to the method for producing this vascular substitute, wherein the collagen compound with a collagen concentration of 4 to 12% by weight is kept at 15 to 30 °C for 18 to 30 hours, and then the non-resorbable knitted fabric layer 2 is integrated in one collagen compound layer to make a collagen compound coating on the inner and outer sides of the non-resorbable knitted fabric layer 2, or the collagen compound with a collagen concentration of 4 to 12% by weight is kept at 15 to 30 °C for 18 to 30 hours, and then the collagen compound is extruded to make the inner resorbable layer (1) in the form of a tube that is dried at the room temperature until pliable, and the inner resorbable layer (1) is overlaid with the non-resorbable knitted fabric layer (2), on which the outer resorbable layer (3) of collagen compound with a collagen concentration of 3 to 12% by weight is extruded, and the vascular substitutes are dried at 15 to 30 °C for 15 to 30 hours until pliable, and then the vascular substitutes are hardened with 1.5 to 3.2% resin for 3 to 10 minutes and then they are dried and softened up in a 15 to 30% glycerine bath for 15 to 25 minutes.

Anmelder

Firmen

Ceske vysoke uceni technicke v Praze
Vseobecná fakultní nemocnice v Praze
Univerzita Karlova
Vyzkumny Ustav Potravinarsky Praha, V.V.I.
Ceske vysoke uceni technicke v Praze, Fakulta strojni, Centrum vozidel udrzitelne mobility

Land

🇨🇿 Tschechien

Fachgebiete