Verfahren zur Herstellung von Hypromellose-Acetat-Succinat

Details

Veröffentlichungs-Nr.

EP3599252

Aktenzeichen

EP19188172

Anmeldetag

24. Juli 2019

Veröffentlichung

28. Dezember 2022

Erteilung

28. Dezember 2022

Rechtsraum

EP

IPC

C08B11/20C08B13/00C08L1/32

Abstract

There is provided a method for producing hypromellose acetate succinate (HPMCAS), the method not requiring any special device and facilitating removal of impurities. More specifically, there is provided a method for producing HPMCAS, including an esterification step of esterifying hypromellose with an acetylating agent and a succinoylating agent in the presence of an aliphatic carboxylic acid to obtain a reaction product solution containing HPMCAS; a precipitation step of precipitating the HPMCAS by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCAS; a neutralization step of neutralizing the suspension with a basic substance to obtain a neutralized suspension; and a washing step of washing the HPMCAS contained in the neutralized suspension to obtain the washed HPMCAS.

Anmelder

Firma

Shin-Etsu Chemical Co., Ltd.

Land

🇯🇵 Japan

Fachgebiete