Filtrationsmodul und Anordnung zum Filtern eines Prozessmediums in einem Bioprozess und Verfahren zur Probenentnahme Während eines Bioprozesses

Details

Veröffentlichungs-Nr.

EP3851827

Aktenzeichen

EP20152273

Anmeldetag

16. Januar 2020

Veröffentlichung

1. Mai 2024

Erteilung

1. Mai 2024

Rechtsraum

EP

IPC

G01N1/20B01D61/12// G01N1/40

Abstract

A filtration module (20) for filtering a process medium in a bioprocess, in particular in a biopharmaceutical process comprises a process flow path for a process medium, a filter membrane (20) coupled to the process flow path, and a sampling membrane (18) coupled both to the process flow path and to a sampling flow path (16) for extracting a sample from the process medium. The sampling flow path (16) guides the extracted sample to a sampling outlet of the filtration module (20) or to an analyzer integrated into the filtration module (20). A filtration assembly comprises such a filtration device and an analyzer coupled to the sampling outlet of the filtration module (20). A method of sampling during a bioprocess comprises the following steps: providing such a filtration module (20); urging a process medium through the process flow path; filtering the process medium by using the filter membrane (20) coupled to the process flow path; extracting a sample from the process medium by using the sampling membrane (18) coupled to both the process flow path and the sampling flow path (16); and guiding the extracted sample to a sampling outlet of the filtration module (20) or to an analyzer integrated into the filtration module (20). A computer program comprises instructions to effect at least one of the following: cause the means for urging the transport medium through the sampling flow path (16) of the filtration assembly to control the flow of the transport medium; control the analyzer of the filtration module (20) or the analyzer of the filtration assembly, especially providing settings and inputs to the analyzer; cause a process control unit of the filtration assembly to evaluate analysis data provided by the analyzer of the filtration module or the analyzer of the filtration assembly, and to adjust or control the bioprocess based on the evaluation

Anmelder

Firma

Sartorius Stedim Biotech GmbH

Land

🇩🇪 Deutschland

Fachgebiete