Verfahren zur Herstellung eines Viralen, eines Vektoriellen oder eines Beliebigen Transportsystems und Krebsspezifischer Crispr-Komplexe

Details

Veröffentlichungs-Nr.

EP4253550

Aktenzeichen

EP22166327

Anmeldetag

1. April 2022

Veröffentlichung

14. Februar 2024

Rechtsraum

EP

IPC

C12N15/86A61P35/00C12N15/11A61K38/46

Abstract

The present invention relates to a method for the manufacture of a viral, a vector or any transport system comprising the steps a) isolation of a class of cells from one or more sample(s) obtained from a subject; b) identifying a nucleic acid sequence that is specific for a subgroup of the class of cells; c) design of guide RNA(s) and/or DNA and/or protein directed against the nucleic acid sequence, and d) cloning of one or more sequence(s) encoding the guide RNA(s) and a Cas endonuclease into a viral system or a vector system, preferably into a viral vector, or including the guide RNA(s) and a Cas endonuclease into a viral, a vector or any transport system; and a composition comprising a viral, a vector or any transport system manufactured according to this method and its use in the treatment of cancer.

Anmelder

Firmen

GenCC GmbH & Co. KG
GenCC GmbH 6 Co. KG

Land

🇩🇪 Deutschland

Fachgebiete