Verfahren, Prozessor und Medizinische Fluoreszenzbeobachtungsvorrichtung mit Zwei Farbbildern zur Aufzeichnung von Fluoreszenz

Details

Veröffentlichungs-Nr.

EP4275580

Aktenzeichen

EP22189296

Anmeldetag

8. August 2022

Veröffentlichung

15. November 2023

Rechtsraum

EP

IPC

A61B1/00A61B1/04G01N21/64G02B21/16

Abstract

This application relates to an image processor and a computer-implemented image processing method for computing a digital fluorescence output color image (160) in a medical fluorescence observation device (100), the medical fluorescence observation device having a white-light color camera (110) for recording one or more digital white-light color images (114) and a fluorescence-light color camera (111) for recording one or more digital fluorescence-light color image (112). The method and the processor (170) are configured to: retrieve a digital white-light color image in which one or more fluorescing fluorophores (116, 118) are represented in a first imaged spectrum (202). The digital white-light color image comprises a plurality of first pixels (150a) and each first pixel (150a) comprises a first set ({R1, B1, G1}) of color space coordinates (R1, B1, G1).The first imaged spectrum (202) overlaps a fluorescence emission spectrum (226) of at least one fluorophore (116) of the one or more fluorescing fluorophores (116, 118). Further, a digital fluorescence-light color image (112) is retrieved, in which the one or more fluorescing fluorophores are represented in a second imaged spectrum (222) different from the first imaged spectrum. The digital fluorescence-light color image comprises a plurality of second pixels (150b) and each second pixel (150b) comprises a second set ({R2, B2, G2}) of color space coordinates (R2, G2, B2). The second imaged spectrum (222) overlaps the fluorescence emission spectrum of the at least one fluorophore. The digital fluorescence output color image is generated from the digital white-light color image and the digital fluorescence-light color image and comprises a plurality of output pixels (150c). A color (R*, G*, B*) of an output pixel (150c) is computed by applying a color conversion function (140) to an input union (846, {R1, R2, G1, G2, B1, B2}) of the first set of color space coordinates of a first pixel (150a) and the second set of color space coordinates of a second pixel (150a). Using the union set at each pixel allows to more reliably detect and enhance fluorescence-related image content, such as excited fluorescence, auto-fluorescence and/or reflectance of an object illuminated with a fluorescence-excitation spectrum.

Anmelder

Firma

Leica Instruments (Singapore) Pte Ltd

Land

🇸🇬 Singapur

Fachgebiete