Verfahren zur Herstellung von L-Carnitin in einem Vollständig Kontinuierlichen Verfahren

Details

Veröffentlichungs-Nr.

EP4275786

Aktenzeichen

EP22172282

Anmeldetag

9. Mai 2022

Veröffentlichung

18. Februar 2026

Erteilung

18. Februar 2026

Rechtsraum

EP

IPC

B01J19/00B01F33/30B01L3/00C07C229/22

Abstract

A full continuous-flow preparation method of L-camitine, including: mixing chlorine gas and a diketene solution via a first micromixer followed by transportation to a first microchannel reactor for continuous chlorination and esterification reaction to obtain 4-chloroacetoacetate; feeding the 4-chloroacetoacetate and a reductase to a second micromixer and a second microchannel reactor in sequence for continuous catalytic reaction to obtain (R)-4-chloro-3-hydroxybutyrate; simultaneously transporting the (R)-4-chloro-3-hydroxybutyrate and a trimethylamine solution to a third micromixer and a third microchannel reactor for continuous substitution and hydrolysis reaction; and subjecting the reaction mixture to desalination and concentration to obtain the L-carnitine. Compared to the existing batch reactor-based synthesis, the method of the disclosure has good safety, shortened reaction time, high degree of automation, desirable time-space efficiency and low energy consumption, and thus is suitable for the industrial production.

Anmelder

Firma

Fudan University

Land

🇨🇳 China

Fachgebiete