Künstlicher Komplex zur Bindung von Chromosomchromatiden

Details

Veröffentlichungs-Nr.

EP4434533

Aktenzeichen

EP23163092

Anmeldetag

21. März 2023

Veröffentlichung

4. Dezember 2024

Erteilung

4. Dezember 2024

Rechtsraum

EP

IPC

A61K38/00C07K14/435C12N15/62G01N33/50C12N5/075

Abstract

During ageing, egg cells display a gradual loss of cohesin complexes. The cohesin loss eventually causes sister chromatids to separate prematurely, which leads to aneuploidy. The inventors engineered an artificial cohesion system, which is a complex for chromatid or chromosome tethering to reduce, for example, age-related premature separation of sister chromatids in eggs. The artificial cohesion system is a complex, which tethers chromosomes or chromatids so that e.g. the risk of aneuploidy is reduced. Said complex comprises (I) one or more first protein(s) and (II) one or more second protein(s), wherein the (I) first and the (II) second protein(s) each comprise (i) a chromatin-binding component, (ii) a protein-binding region being N-terminal of the chromatin-binding component, (iii) a protein-binding region being C-terminal of the chromatin-binding component. The present invention also includes nucleic acid molecule(s) encoding said complex. Furthermore, several in vitro methods concerning the complex or the nucleic acid molecule(s) encoding said complex also form part of the invention.

Anmelder

Firma

Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

Land

🇩🇪 Deutschland

Fachgebiete