Schätzung von Pharmakokinetischen (pk)-Parametern von Wirkstoffkandidaten unter Verwendung Universeller Pk-Parametergrenzen

Details

Veröffentlichungs-Nr.

EP4510138

Aktenzeichen

EP24153674

Anmeldetag

24. Januar 2024

Veröffentlichung

19. Februar 2025

Rechtsraum

EP

IPC

G16C20/30

Abstract

Developability of a drug candidate is decided based on the Pharmacokinetic (PK) and Pharmacodynamic (PD) parameters of the drug candidate under investigation. Present disclosure provides systems and methods that are implemented using universal PK parameters' bounds and optimization technique(s) to produce robust and optimized set of PK parameters. More specifically, the system and method for estimating optimized set of PK parameters by a) creating universal parameter bounds, b) performing logical operations on universal PK parameters' bounds to create multiple bound combinations c) computing a performance threshold for residual sum of squares (RSS) d) performing global optimization to estimate globally optimized set of PK parameters act as initial PK parameters and e) performing local optimization of initial PK parameters to estimate locally optimized set of PK parameters, the best PK parameters that can used for assessing the developability of drug candidates within Pharmaceutical industry.

Anmelder

Firma

Tata Consultancy Services Limited

Land

🇮🇳 Indien

Fachgebiete