Verfahren zur Bestimmung der Thymusfunktion durch ein Tröpfchen-Digital-Pcr-System

Details

Veröffentlichungs-Nr.

EP4553174

Aktenzeichen

EP23383145

Anmeldetag

8. November 2023

Veröffentlichung

14. Mai 2025

Rechtsraum

EP

IPC

C12Q1/6883

Abstract

The invention disclosed herein provides an in vitro and/or ex vivo method to assess and monitoring thymic function and also an in vitro and/or ex vivo method for prognosis and/or diagnosis of immune system dysfunction in an isolated biological sample from an individual comprising the detection of the sj/β-TREC (T-cell receptor Rearrangement Excision Circles) ratio by droplet digital PCR (ddPCR). Moreover, the present invention also relates to the in vitro and/or ex vivo use of the sj/DβJβ-TREC ratio as a biomarker for the assess and monitoring thymic function and methods for the prognosis and/or diagnosis of immune system dysfunction in an isolated sample of an individual by a ddPCR. In addition, the present invention also refers to a kit for use in these methods.

Anmelder

Firmen

Consejo Superior De Investigaciones Científicas
Servicio Andaluz de Salud

Land

🇪🇸 Spanien

Fachgebiete