Produktherstellungsverfahren, Hohlfasermembranfilter und Produktherstellungsvorrichtung

Details

Veröffentlichungs-Nr.

EP4711467

Anmeldetag

3. Juni 2024

Veröffentlichung

12. Dezember 2024

Rechtsraum

EP

Abstract

Provided is a method for manufacturing a product, including a culture step of culturing cells in a culture solution accommodated in a tank having a capacity of 100 L or more, and a separation step of using a hollow fiber membrane filter which has a hollow fiber membrane having a primary flow passage extending in a longitudinal direction inside the hollow fiber membrane and has a housing accommodating a plurality of the hollow fiber membranes, the hollow fiber membrane filter having a secondary flow passage in a space of the housing outside each of the hollow fiber membranes, to feed the culture solution supplied from the tank to the primary flow passage, and allowing a permeated liquid containing the product to permeate through the secondary flow passage to separate the cells and the product in the culture solution from each other, in which, in the separation step, in a case where a difference in pressure between both ends of the primary flow passage on a supply side and a discharge side during the feeding of the culture solution is denoted as ΔP [Pa], and a viscosity of the culture solution is denoted as µ [Pa·s], ΔP/µ during the feeding of the culture solution is 4.9 × 10⁶ [1/s] or less.

Anmelder

Firma

FUJIFILM Corporation

Land

🇯🇵 Japan