Breitbandverfahren zur Signalverstärkung von Magnetresonanzkontrastmitteln im Sekundenbereich und deren Reinigung
Anmelder: Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V. 🇩🇪
Details
- Veröffentlichungs-Nr.
- EP4711794
- Anmeldetag
- 26. August 2022
- Veröffentlichung
- 18. März 2026
- Rechtsraum
- EP
- IPC
- G01R33/56(AXELSSON OSKAR et al.)
Abstract
The present invention relates to a method for transferring a two-spin order of a molecule (e.g. parahydrogen) into a hyperpolarization of at least one heteronucleus, the method comprising the steps of: providing a molecule (e.g. parahydrogen pH<sub>2</sub>) comprising two protons and at least one heteronucleus (S<sub>3</sub>, S<sub>4</sub>), the protons having nuclear spins being coupled to a nuclear spin of the at least one heteronucleus; exposing the protons and the at least one heteronucleus to an e.g. homogeneous magnetic field (B<sub>0</sub>) in a z-direction, the z-direction forming a right-handed orthogonal coordinate system with an x- and a y-direction; and applying a sequence of radio frequency pulses to the protons and the at least one heteronucleus in order to transfer said two-spin order into the hyperpolarization of the at least one heteronucleus, wherein said sequence of radio frequency pulses comprises a first, a second, and a third group (N<sub>A</sub>, N<sub>B</sub>, N<sub>C</sub>) of 180° radio frequency pulses, wherein the first group (N<sub>A</sub>) of 180° radio frequency pulses is consecutively applied n<sub>A</sub> times during a first time interval (τ<sub>A</sub>) and wherein the second group (N<sub>B</sub>) of 180° radio frequency pulses is consecutively applied n<sub>B</sub> times during a second time interval (τ<sub>B</sub>) after the last first group, and wherein the third group (N<sub>C</sub>) of 180° radio frequency pulses is consecutively applied n<sub>C</sub> times during a third time interval (τ<sub>C</sub>) after the last second group, wherein n<sub>A</sub>, n<sub>B</sub>, n<sub>C</sub> are integer numbers, respectively.
Anmelder
- Firma
- Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.
- Land
- 🇩🇪 Deutschland
Deutsche gemeinnützige Forschungsorganisation mit Sitz in München. Die Max-Planck-Gesellschaft betreibt zahlreiche Institute für Grundlagenforschung in Natur-, Geistes- und Sozialwissenschaften.
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