Stoffwechselnetzwerkverarbeitungssystem und Stoffwechselnetzwerkverarbeitungsverfahren

Details

Veröffentlichungs-Nr.

EP4712083

Anmeldetag

12. Mai 2023

Veröffentlichung

21. November 2024

Rechtsraum

EP

IPC

G16B5/00

Abstract

The present disclosure proposes, as an example, a metabolic network processing technique which is related to a metabolic network processing system for extracting and proposing a modified enzyme that achieves a target yield of a target substance in a metabolic network in order to constantly predict an increase or decrease in a yield of the target substance when a modification of the enzyme is proposed based on a structural sensitivity analysis. A control device executes (i) processing of generating N sensitivity matrices by using a stoichiometric matrix obtained by converting the metabolic network, a basis c of a kernel of the stoichiometric matrix, and a given probability distribution, (ii) processing of calculating, by checking a sign of each matrix element in the N sensitivity matrices and calculating a proportion of the sign in each matrix element, a confidence level of each matrix element, (iii) processing of extracting k matrix elements having high confidence levels among confidence levels for the number of matrix elements in the sensitivity matrix as modified enzymes, and (iv) processing of outputting the extracted k modified enzymes

Anmelder

Firma

Hitachi, Ltd.

Land

🇯🇵 Japan