Verwendung einer Struktur zur Nukleinsäureabgabe bei der Behandlung von Hämatopoietischen Tumoren
Anmelder: Japan Science and Technology Agency 🇯🇵
Details
- Veröffentlichungs-Nr.
- EP4714453
- Anmeldetag
- 17. Mai 2024
- Veröffentlichung
- 28. November 2024
- Rechtsraum
- EP
Abstract
The present disclosure is a nucleic acid delivery construct used for treatment of a hematologic malignancy, the nucleic acid delivery construct having an assembly structure in which a nucleic acid analog represented by the following formula (1) and a nucleic acid to be delivered containing a microRNA that regulates a network of the oncogene KRAS are assembled with each other through electrostatic interaction. Wherein N represents a cationic artificial nucleic acid, H represents a hydrophilic polymer, S1 represents a spacer 1, S2 represents a spacer 2, and L represents a ligand; N has structural units in which a base is bonded to a hexose selected from ribose and deoxyribose, linking structures linking two of the structural units, and a backbone structure having cationic groups; and the cationic artificial nucleic acid is capable of assembling through electrostatic interaction between a phosphate group of the nucleic acid to be delivered and the cationic group.
Anmelder
- Firma
- Japan Science and Technology Agency
- Land
- 🇯🇵 Japan
Japanische staatliche Förderorganisation für Wissenschaft und Technologie, die Forschungsprojekte finanziert und den Technologietransfer zwischen Universitäten und Industrie unterstützt. Die Behörde untersteht dem japanischen Bildungsministerium.
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