Sequenzerzeugungsvorrichtung und Sequenzerzeugungsverfahren

Details

Veröffentlichungs-Nr.

EP4723121

Anmeldetag

29. Januar 2024

Veröffentlichung

5. Dezember 2024

Rechtsraum

EP

Abstract

A sequence generation device according to the present disclosure includes a sequence proxy evaluation unit that calculates a proxy evaluation value for a sequence including a plurality of amino acids, and a sequence generation unit that generates the sequence using a learning model, in order to generate various sequences while maintaining high binding affinity. The sequence generation unit changes some of the amino acids in the sequence generated by the learning model with a predetermined probability, selects an amino acid after change using a probability density function such that the amino acid having a characteristic closer to that of the amino acid before change is selected with a higher probability, trains the learning model to generate a sequence indicating a higher proxy evaluation value based on the proxy evaluation value for the sequence after the amino acid is changed, thereby generating a trained model, and generates a generation sequence using the trained model (see FIG. 3).

Anmelder

Firma

Hitachi, Ltd.

Land

🇯🇵 Japan