Polymere Prodrug-Nanopartikel für Tumorgerichtete Ultraschallaktivierte Krebstherapie

Details

Veröffentlichungs-Nr.

EP4725504

Anmeldetag

14. Oktober 2024

Veröffentlichung

15. April 2026

Rechtsraum

EP

Abstract

A polymeric prodrug nanoparticle for the targeted accumulation and activation in tumor tissue, consisting of the following monomers:a) at least one platinum(IV) complex andb) at least one sonosensitizer, andc) a compound having a hydrophilic group providing this hydrophilic group at each terminal end of the prodrug nanoparticle, wherein a), b) and c) are each covalently bonded to one another by means of a linker and a) and b) are arranged stochastically distributed within the polymeric prodrug nanoparticle can be used to treat tumors and in particular metastases in a way that is well tolerated by the body. Upon irradiation of the polymeric prodrug nanoparticle with ultrasound, the platinum(IV) prodrug is activated in the tumor region, resulting in the release of cytotoxic platinum and killing of tumor cells.

Anmelder

Firma

Schleuning, Christian

Land

🇩🇪 Deutschland