Arylamidderivat mit Antitumoraktivität

Details

Veröffentlichungs-Nr.

EP4725941

Anmeldetag

21. Januar 2021

Veröffentlichung

15. April 2026

Rechtsraum

EP

Abstract

The present invention relates to a MEK-inhibiting agent comprising as an active ingredient a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or salt: <img class="EMIRef" id="7daffbbd-4fef-4755-83f0-674c51246527-ia01" /> wherein: ring A is a group represented by general formula (2), (3) or (4) below (where the bonds denoted by *, ** and *** are bonded to -NH-, -CONH- and -CH<2>-, respectively): <img class="EMIRef" id="7daffbbd-4fef-4755-83f0-674c51246527-ia02" /> X<1>, X<2>, X<3>, X<4> and X<5> are each independently -CR<2>= or -N=; R<2> is a hydrogen atom, a halogen atom, or a Cl-4 alkyl group; R<1> is -S(=O)<2>-NH-R<8> or -S(=O)<2>-R<8>; R<8> is a C1-4 alkyl group (the C1-4 alkyl group being optionally substituted with a halogen atom, a hydroxy group, a C1-4 alkoxy group, a C3-6 cycloalkyl group or a C3-6 heterocycloalkyl group) or a C3-6 cycloalkyl group (the C3-6 cycloalkyl group being optional substituted with a C1-4 alkyl group); R<3> is a hydrogen atom, a C3-6 cycloalkyl group, or a C1-6 alkoxy group; R<5> is a halogen atom; R<6> is a hydrogen atom and R<4> is a halogen atom or a C3-6 cycloalkyl group; R<7> is a C1-4 alkyl group; and R<9> is a hydrogen atom.

Anmelder

Firma

CHUGAI SEIYAKU KABUSHIKI KAISHA

Land

🇯🇵 Japan