Verfahren, System und Vorrichtung zur Titerschätzung für Immunglobulin-Einzeldomänenmoleküle

Details

Veröffentlichungs-Nr.

EP4730342

Anmeldetag

18. Oktober 2024

Veröffentlichung

22. April 2026

Rechtsraum

EP

IPC

G16B40/20(KUCIA JUSTYNA et al.)(GENENTECH INC et al.)(SIMMONS LAURA et al.)

Abstract

Methods, systems and apparatus are described for estimating titer of immunoglobulin single variable domains (ISVDs). The method includes: receiving an ISVD sequence dataset comprising data representative of at least one ISVD sequence; processing the received ISVD sequence dataset with a protein large language model configured for generating an ISVD embeddings dataset; processing the ISVD embeddings dataset with a ML model configured for generating an estimated ISVD titer value for each ISVD sequence of the ISVD sequence dataset based on the ISVD embeddings dataset input; and outputting data representative of the ISVD titer values corresponding to the ISVD sequence dataset for downstream processing.

Anmelder

Firma

Sanofi

Land

🇫🇷 Frankreich