Arzneimittelentdeckungsunterstützungsvorrichtung, Verfahren zum Betrieb einer Arzneimittelentdeckungsunterstützungsvorrichtung und Programm zum Betrieb einer Arzneimittelentdeckungsunterstützungsvorrichtung

Details

Veröffentlichungs-Nr.

EP4730345

Anmeldetag

11. Juni 2024

Veröffentlichung

19. Dezember 2024

Rechtsraum

EP

IPC

G16C20/30, C12Q1/02, G01N33/50

Abstract

A drug discovery support apparatus includes a processor, and the processor is configured to: acquire a first prediction value of a degree of inhibition indicating a degree to which a flow of ions in a plurality of ion channels present in an iPS myocardial cell, which is a myocardial cell derived from a human iPS cell, is inhibited by a candidate substance for a drug for each of the ion channels and for each added amount of the candidate substance, the first prediction value being output from a prediction model based on a first fluctuation waveform that is a fluctuation waveform of an extracellular potential of the iPS myocardial cell and is measured in a case where the candidate substance is added to the iPS myocardial cell while the added amount is changed; derive an index value indicating a dose-response relationship of the candidate substance for each of the ion channels, based on the first prediction value for each added amount; and present, to a user, estimated reference information that corresponds to the index value and is referred to in order to estimate a mechanism of action of the candidate substance.

Anmelder

Firma

FUJIFILM Corporation

Land

🇯🇵 Japan