Zusammensetzungen und Verfahren zur Abgabe von Nukleinsäuren an Zellen

Details

Veröffentlichungs-Nr.

EP4736889

Anmeldetag

31. August 2020

Veröffentlichung

6. Mai 2026

Rechtsraum

EP

IPC

A61K48/00(UNIV YALE et al.)(GEALL ANDREW JOHN et al.)ZETSCHE ET AL., CELL, 2015

Abstract

Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex.

Anmelder

Firma

Yale University

Land

🇺🇸 USA