Polypeptid aus der Leichtkette eines Antikörpers mit HER2-Abbauaktivität, HER2-Bindendes Polypeptid Damit, Verfahren zur Herstellung Dieser Polypeptide und Verwendung Dieser Polypeptide
Anmelder: Japan Science and Technology Agency 🇯🇵
Details
- Veröffentlichungs-Nr.
- EP4737480
- Anmeldetag
- 28. Juni 2024
- Veröffentlichung
- 2. Januar 2025
- Rechtsraum
- EP
Abstract
The present invention provides an antigenase obtained by imparting high enzymatic activity to an antibody having a high anticancer effect. The present invention relates to a polypeptide including hypervariable regions derived from an anti-HER2 antibody light chain, as described in (1a) or the like: (1a) a polypeptide consisting of an amino acid sequence that includes a CDR1 region consisting of an amino acid sequence set forth in SEQ ID NO: 1, a CDR2 region consisting of an amino acid sequence set forth in SEQ ID NO: 2, and a CDR3 region consisting of an amino acid sequence set forth in SEQ ID NO: 3, and has an aspartic acid residue at position 70 of a variable region in accordance with the Kabat numbering scheme, wherein proline residues at positions 95 and 96 of a variable region in accordance with the Kabat numbering scheme are deleted or substituted with amino acid residues other than proline residues.
Anmelder
- Firma
- Japan Science and Technology Agency
- Land
- 🇯🇵 Japan
Japanische staatliche Förderorganisation für Wissenschaft und Technologie, die Forschungsprojekte finanziert und den Technologietransfer zwischen Universitäten und Industrie unterstützt. Die Behörde untersteht dem japanischen Bildungsministerium.
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