Stabilisierung der Menschlichen Spindel durch KIFC1/HASET

Details

Veröffentlichungs-Nr.

EP4748388

Anmeldetag

25. Juli 2022

Veröffentlichung

27. Mai 2026

Rechtsraum

EP

IPC

C12N5/075, A61K38/17A61K38/17

Abstract

It has been surprisingly found that human oocytes lack the important spindle-associated protein KIFC1/HSET. The application describes a method stabilising the human spindle with KIFC1/HSET. Specifically, the method relates to introducing (i) KIFC1/HSET protein or (ii) mRNA encoding KIFC1/HSET into a human oocyte. Furthermore, the application relates to a non-naturally occurring human oocyte, wherein a (i) KIFC1/HSET protein or (ii) KIFC1/HSET mRNA has been introduced into a naturally occurring human oocyte thereby obtaining the non-naturally occurring oocyte. Additionally, the application relates to a (i) KIFC1/HSET protein or (ii) mRNA encoding the KIFC1/HSET for use in a method of lowering the probability of having a disorganized and/or a multipolar spindle during mitosis in a human zygote by introducing the (i) KIFC1/HSET protein or (ii) mRNA encoding the KIFC1/HSET into the human zygote. Moreover, the application discloses a complex comprising (i) a KIFC1/HSET protein and (ii) a human meiotic spindle or a human mitotic spindle, wherein the KIFC1/HSET protein has been introduced into a human oocyte or zygote.

Anmelder

Firma

Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.

Land

🇩🇪 Deutschland

Fachgebiete