Verfahren und Systeme zum Nachweis von Mikrosatelliteninstabilität von Krebs in einem Flüssigen Biopsietest
Anmelder: Tempus AI, Inc. 🇺🇸
Details
- Veröffentlichungs-Nr.
- EP4749655
- Anmeldetag
- 31. Juli 2020
- Veröffentlichung
- 27. Mai 2026
- Rechtsraum
- EP
- IPC
- G16H50/30
Abstract
Methods, systems, and software are provided for determining a microsatellite instability (MSI) status of a subject. Nucleotide sequences are obtained for cell-free DNA molecules from a liquid biopsy sample of the subject. The nucleotide sequences are used to determine, for each respective microsatellite locus in a plurality of predetermined microsatellite loci, one or more independent corresponding metrics, where each metric in the one or more metrics is determined at least in part by the distribution of the number of repeat units at the respective microsatellite locus. The one or more metrics are input into a classifier trained to distinguish between stable and unstable microsatellite loci, in order to classify the MSI status of the subject. In certain aspects, microsatellite stability metrics are compared against metrics from solid tumor samples and/or normal tissues. In certain aspects, the microsatellite stability metrics are determined relative to a subject-specific standard for microsatellite stability.
Anmelder
- Firma
- Tempus AI, Inc.
- Land
- 🇺🇸 USA
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