Verfahren und Zusammensetzungen zur Transduktion und Expansion von Lymphozyten und Regulierung der Aktivität davon

Details

Veröffentlichungs-Nr.

EP4752227

Anmeldetag

3. März 2018

Veröffentlichung

3. Juni 2026

Rechtsraum

EP

IPC

C12N15/86

Abstract

The present disclosure provides methods for genetically modifying lymphocytes and methods for performing adoptive cellular therapy that include transducing T cells and/or NK cells. The methods can include inhibitory RNA molecule(s) and/or engineered signaling polypeptides that can include a lymphoproliferative element, and/or a chimeric antigen receptor (CAR), for example a microenvironment restricted biologic CAR (MRB-CAR). Additional elements of such engineered signaling polypeptides are provided herein, such as those that drive proliferation and regulatory elements therefor, as well as replication incompetent recombinant retroviral particles and packaging cell lines and methods of making the same. Numerous elements and methods for regulating transduced and/or genetically modified T cells and/or NK cells are provided, such as, for example, those including riboswitches, MRB-CARs, recognition domains, and/or pH-modulating agents.

Anmelder

Firma

Exuma Biotech Corp.

Land

🇺🇸 USA

Fachgebiete