Weg zur Heilung von Morbus Parkinson

Details

Veröffentlichungs-Nr.

EP4755391

Anmeldetag

4. Dezember 2025

Veröffentlichung

10. Juni 2026

Rechtsraum

EP

Abstract

Neurological disorders, Parkinson's disease and Multiple System Atrophy (MSA) cause serious socio-economic problems as there are, at present only therapies that treat the symptoms. Parkinson's research is a highly competitive field focusing on the specific drug targeting of the aggregation of alpha-synuclein (SYN). The discovery of Tubulin Polymerization Promoting Protein (TPPP) was a crucial factor in anti-Parkinson research. TPPP is a prominent pathological partner of SYN, which shifts the SYN-SYN aggregation toward the formation of fatal SYN-TPPP assemblies. The disassembly of the SYN-TPPP by specific agents may eliminate the toxicity of the pathological assembly of SYN by the proteolytic degradation of the excess SYN and leads to the recovery of the physiologically active proteins.

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Firma

HUN-REN Természettudományi Kutatóközpont

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