Funktionalisierte Atp-Hydrolysierende Enzymzusammensetzungen

Details

Veröffentlichungs-Nr.

EP4763197

Anmeldetag

19. Dezember 2024

Veröffentlichung

24. Juni 2026

Rechtsraum

EP

IPC

A61K9/50, A61K9/51, A61K38/46

Abstract

The present invention relates to a composition comprising a solid carrier, a protein ATP-hydrolyzing enzyme or a fragment thereof immobilized on the surface of the solid carrier, a protective layer to protect the protein ATP-hydrolyzing enzyme or a fragment thereof by embedding the protein ATP-hydrolyzing enzyme or a fragment thereof, and a functional constituent immobilized on the surface of the protective layer, wherein the functional constituent immobilized on the surface of the protective layer is a polymer comprising repeat units wherein each repeat unit comprises at least one amino group and/or at least one thiol group. The present invention also relates to methods of producing said composition and uses of the composition for the prevention, delay of progression or treatment of dysbiosis or a dysbiosis-related disease. The present invention also relates to a pharmaceutical combination comprising (i) said composition; and (ii) an immune checkpoint modulator and uses thereof for the prevention, delay of progression or treatment of cancer and/or for use in adoptive (T) cell therapy.

Anmelder

Firmen

MV Biotherapeutics SA
Perseo Pharma AG

Land

🇨🇭 Schweiz

Fachgebiete