Funktionalisierte Enzymzusammensetzungen mit Verzweigtkettiger Aminosäureabbau

Details

Veröffentlichungs-Nr.

EP4763227

Anmeldetag

19. Dezember 2024

Veröffentlichung

24. Juni 2026

Rechtsraum

EP

Abstract

The present invention relates to a composition comprising a solid carrier, a protein branched-chain amino acid-degrading enzyme or a fragment thereof immobilized on the surface of the solid carrier, a protective layer to protect the protein branched-chain amino acid-degrading enzyme or a fragment thereof by embedding the protein branched-chain amino acid-degrading enzyme or a fragment thereof, and a functional constituent immobilized on the surface of the protective layer, wherein the functional constituent immobilized on the surface of the protective layer is a polymer comprising repeat units wherein each repeat unit comprises at least one amino group and/or at least one thiol group. The present invention also relates to methods of producing said composition and uses of the composition for the prevention, delay of progression or treatment of branched-chain amino acid metabolism related diseases.

Anmelder

Firma

Perseo Pharma AG

Land

🇨🇭 Schweiz