Verfahren zur Bestimmung eines Optimalen Dosierungsplans für Arzneimittel

Details

Veröffentlichungs-Nr.

EP4765141

Anmeldetag

20. Dezember 2024

Veröffentlichung

24. Juni 2026

Rechtsraum

EP

IPC

G16H20/10, G16H70/40

Abstract

Method implemented by a computer for determining at least one optimal drug dosing regimen to treat a patient (2) efficiently against at least one drug-sensitive pathogenic agent responsible for infection, said method comprising the following steps:a. obtaining patient-related data related to said patient (2), such as birth date, gender, weight, creatinemia, and co-treatments;b. obtaining drug-related data, said drug-related data including parameters selected from :i. the drug, the route of administration when several routes exist for said drug and the adaptation type as "a posteriori" or "a priori" ;ii. the drug treatment regimen;wherein the process comprises a next step of:c. determine values for pharmacokinetic parameter for efficacy PPE and pharmacokinetic parameter for toxicity PPT from the patient related data, the drug related data and at least one population pharmacokinetic model for "a priori" adaptation and for "a posteriori" adaptation, when PPE and PPT are not obtained directly with the measured concentration(s);d. obtaining infection related data comprising parameters selected from the documentation of infection, the infection localization, the type of infection, the pathogen if identified, the susceptibility of the pathogen to the antifungigram/antibiogram, and the MIC if determined;wherein the process further comprises next steps of:e. Determination of an efficacy target for the drug from at least the infection related data;f. Determination of a target at risk of toxicity; and,g. Determination of at least one optimal dosing regimen of the drug by comparison of pharmacokinetic parameter of efficacy PPE with the efficacy target and the pharmacokinetic parameter of toxicity PPT with the risk of toxicity target.

Anmelder

Firmen

Assistance Publique - Hôpitaux de Paris
Université Paris Cité

Land

🇫🇷 Frankreich