Makrocyclische Peptidverbindung mit Zellmembranpermeabilität und Metabolischer Stabilität und Bibliothek damit

Details

Veröffentlichungs-Nr.

EP4768499

Anmeldetag

5. November 2024

Veröffentlichung

15. Mai 2025

Rechtsraum

EP

IPC

C07K7/54, C40B40/10

Abstract

The present invention provides a cyclic peptide compound optionally linked to a nucleic acid, wherein the cyclic peptide compound contains a cyclic portion, (1) the cyclic portion is composed of 13 or 14 amino acid residues, (2) among the amino acid residues composing the cyclic portion, the number of N-substituted amino acid residues is 7 or more, the number of amino acid residues having the same side chain is 3 or less, and the number of natural amino acid residues is 4 or less, and (3) ClogP/total amide bond (ClogP/total AB) is 1.0 to 1.8.

Anmelder

Firma

Chugai Seiyaku Kabushiki Kaisha

Land

🇯🇵 Japan

Fachgebiete