Dendritische Zelle und Herstellungsverfahren und Anwendung davon

Details

Veröffentlichungs-Nr.

EP4779018

Anmeldetag

16. Januar 2026

Veröffentlichung

22. Juli 2026

Rechtsraum

EP

IPC

C12N5/0784, C07K14/705

Abstract

This application discloses a dendritic cell (DC) and a preparation method and application thereof, belonging to the technical field of immune cells. The DC is a DC that does not express HLA-I class molecules, obtained by knocking out HLA-I class genes in a starting DC. In its application, according to an HLA-I class molecule subtype of a target antigen-specific T cell to be obtained, HLA-I class molecules that match the target antigen-specific T cells can be re-expressed in the DC through gene editing, viral, or mRNA techniques, thereby overcoming the HLA-I class molecule-specific matching restriction that exists when using allogeneic DCs, and solving the problem of insufficient HLA-I class molecule subtype coverage of a single DC.

Anmelder

Firma

Beijing DCT Cell Technology Co., Ltd.

Land

🇨🇳 China

Fachgebiete