Matrix zur Extrakorporalen Entfernung von Mt-Dna aus Blut

Details

Veröffentlichungs-Nr.

EP4786984

Anmeldetag

31. Januar 2025

Veröffentlichung

5. August 2026

Rechtsraum

EP

Abstract

The invention relates to a matrix configured for use in an extracorporeal blood treatment device, wherein the matrix comprises a solid substrate, to which an agent is immobilized, wherein said agent specifically binds mitochondrial DNA (mtDNA) in the blood or blood plasma of a subject. The invention also relates to methods for preparing the matrix according to the present invention, wherein the oligonucleotide and/or the polypeptide is immobilized on the solid substrate of the matrix by covalent coupling, preferably by crosslinking. The invention further relates to a blood treatment device configured to remove mtDNA from the blood or blood plasma of a person in need thereof in an extracorporeal blood circuit, wherein the device comprises a matrix according to the present invention. The invention further relates to an extracorporeal blood circuit comprising a blood treatment device according to the present invention, wherein the extracorporeal blood circuit comprises means for transporting blood or blood plasma from a patient's vascular system to the blood treatment device at a defined flow rate and means for returning the treated blood or blood plasma back to the patient.

Anmelder

Firmen

Bornstein, Stefan
Tselmin, Sergey
Rodionov, Roman
Jarzebska, Natalia
King's College London

Land

🇩🇪 Deutschland