Peptidhydrogele und Ihre Verwendung zur Skelettmuskelregeneration als Stimulatoren der Myoblastenmigration und -Fusion
Anmelder: Uniwersytet Warszawski, Uniwersytet Gdanski 🇵🇱
Details
- Veröffentlichungs-Nr.
- EP4792824
- Anmeldetag
- 19. Dezember 2025
- Veröffentlichung
- 19. August 2026
- Rechtsraum
- EP
Abstract
A peptide-based hydrogel for skeletal muscle regeneration, comprising: a) a self-assembling RADA16-I peptide forming a nanofibrous hydrogel matrix; and b) at least one bioactive peptide selected from: peptide fragment of stromal cell-derived factor 1 (SDF-1): SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 5, SEQ ID NO: 6, or peptide fragment of interleukin-4 (IL-4): SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 7, SEQ ID NO: 8, wherein the bioactive peptide is covalently linked to the RADA16-I sequence via a matrix metalloproteinase (MMPs) cleavable peptide linker and wherein cleavage of the linker by an MMPs results in controlled, localized release of the bioactive peptide in the microenvironment of regenerating muscle tissue.
Anmelder
- Firmen
- Uniwersytet Warszawski
Uniwersytet Gdanski - Land
- 🇵🇱 Polen