Lipidverbindung und Zusammensetzung zur Gewebespezifischen Abgabe eines Wirkstoffs

Details

Veröffentlichungs-Nr.

EP4796555

Anmeldetag

21. Oktober 2024

Veröffentlichung

24. April 2025

Rechtsraum

EP

Abstract

The present invention relates to a novel lipid compound for tissue-specific delivery and a lipid nanoparticle (LNP) composition comprising the same. The lipid nanoparticle comprises, as a component, a lipid compound modified such that an active substance therein is selectively delivered into cells of a specific tissue such as lymph nodes, spleen, retina, tumors, brain, liver, and the like in vivo, thereby preventing side effects and safely achieving desired therapeutic efficacy. These tissue-specific, non-viral LNP delivery systems can be effectively utilized for the prevention of infectious diseases and the treatment of rare and intractable (inherited) diseases (e.g., macular degeneration, diabetic retinopathy, inherited retinal diseases, cancer, brain diseases, liver diseases, etc.), where efficient and selective delivery to the targeted site in the body is crucial.

Anmelder

Firma

Korea Research Institute of Bioscience and Biotechnology

Land

🇰🇷 Südkorea