Säureresistenter Kluyveromyces Marxianus-Stamm und Verwendung davon

Details

Veröffentlichungs-Nr.

EP4796628

Anmeldetag

24. Oktober 2024

Veröffentlichung

1. Mai 2025

Rechtsraum

EP

Abstract

The present invention relates to the technical field of microorganisms, and in particular to an acid-resistant Kluyveromyces marxianus strain and the use thereof. The provided Kluyveromyces marxianus DLY-KMPMFF-0329 is deposited in the China General Microbiological Culture Collection Center with a deposit number of CGMCC No.27009. The strain can tolerate a high concentration of succinic acid and low pH conditions, can efficiently use glucose to synthesize succinic acid by means of the reductive tricarboxylic acid cycle pathway, and can achieve a relatively high production and yield of succinic acid. In addition, the strain has a relatively high homologous recombination efficiency, so that efficient gene editing can be achieved. The strain can be used not only as a succinic acid-producing strain for the fermentation production of succinic acid, but also as a starting strain for breeding or constructing a high-yield succinic acid-producing strain, and has a good application value.

Anmelder

Firmen

China Petroleum & Chemical Corporation
Sinopec Dalian Research Institute of Petroleum and Petrochemicals Co., Ltd.

Land

🇨🇳 China