Verfahren und Systeme zur Bestimmung der Biokompatibilität von Materialien

Details

Veröffentlichungs-Nr.

EP4800382

Anmeldetag

26. Februar 2025

Veröffentlichung

2. September 2026

Rechtsraum

EP

Abstract

A method and system for determining biocompatibility ("BC") of a biological sample ("S") with a solid test material ("M"). A testing apparatus (100) comprises a material region (10R) containing the solid test material ("M"); and a sample region (20R) containing the biological sample ("S") comprising biological cells ("Sc") into which nanocrystals ("NC") with color centers ("CC") have been introduced. A liquid medium ("L") fluidly connects the material region (10R) with the sample region (20R) and carries dissolvable components ("Mc") from the solid test material ("M") into contact with the biological cells ("Sc"). Optical measurements are performed on the biological sample ("S") to determine a time-dependent spin state of the color centers ("CC") of the respective nanocrystals ("NC") as local indicators of a biological response ("Br") of the biological cells ("Sc") to the dissolvable components ("Mc"). The biocompatibility ("BC") is determined based on the optical measurements.

Anmelder

Firmen

RIJKSUNIVERSITEIT GRONINGEN
Academisch Ziekenhuis Groningen

Land

🇳🇱 Niederlande