Virusähnlicher Strukturierter Nanoverbinder und Verwendung davon
Anmelder: Eye Hospital of Shandong First Medical University (Shandong Eye Hospital) 🇨🇳
Details
- Veröffentlichungs-Nr.
- EP4806906
- Anmeldetag
- 13. März 2026
- Veröffentlichung
- 16. September 2026
- Rechtsraum
- EP
- IPC
- C07K14/005
Abstract
A virus-like structured nano-connector, it is based on a hepatitis B virus core protein uniprot P03146 with a C-terminal nucleic acid-binding domain of positions 145-183 (preferably 150-183) being removed, and its spike region and/or N-terminal are respectively inserted with CBP as shown in SEQ ID NO. 01. The present disclosure is constructed based on a collagen-binding polypeptide (CBP) designed by bionic decorin, it is intended to mimic interaction between the native decorin and collagen fibers, enabling efficient penetration across a corneal epithelial barrier and repairing corneal stroma via a non-photocrosslinking approach, thus overcoming limitations associated with the existing clinical therapies.
Anmelder
- Firma
- Eye Hospital of Shandong First Medical University (Shandong Eye Hospital)
- Land
- 🇨🇳 China