Abitz & Partner

This invention provides a method for treating a subject afflicted with cancer, comprising administering to the subject (i) a BCL-2 inhibitor in conjunction with (ii) an alpha-emitting isotope-labeled agent that targets cancer cells in the subject, wherein the amounts of the BCL-2 inhibitor and labeled agent, when administered in conjunction with one another, are therapeutically effective. This invention also provides a method for inducing the death of a cancer cell, comprising contacting the cell with (i) a BCL-2 inhibitor in conjunction with (ii) an alpha-emitting isotope-labeled agent that targets the cancer cell, wherein the amounts of BCL-2 inhibitor and labeled agent, when concurrently contacted with the cell, are effective to induce the cell's death.

The invention relates to an aerosol-generating article. The aerosol-generating article comprises an upstream element. The aerosol-generating article comprises an aerosol-forming substrate in an aerosol-forming substrate portion. The aerosol-forming substrate portion is located downstream of the upstream element. The aerosol-generating article comprises a substrate wrapper at least partly circumscribing the aerosol-forming substrate portion. The substrate wrapper does not extend beyond ends of the aerosol-forming substrate portion in a longitudinal direction of the aerosol-generating article. The substrate wrapper has a thickness of 50 micrometers or more. The invention further relates to an aerosol-generating system.

The problem of the present invention is to provide a novel polytetrafluoroethylene porous film having a small pore diameter, small film thickness, high porosity, and high strength, and a production method thereof. The present invention provides a polytetrafluoroethylene porous film, wherein a bubble point in isopropyl alcohol (IPA) according to JIS K3832 is not less than 400 kPa, and a tensile strength based on JIS K6251 is not less than 50 MPa.

The invention relates to an aerosol-generating system for generating an inhalable aerosol. The system comprises an electric heater for vaporizing an aerosol-forming substance, a control unit, a battery for powering the electric heater, a temperature sensor for detecting the initiation of the electric heater, wherein the temperature sensor is connected to the control unit, a housing encompassing the electrical heater, the battery, and the control unit, and a replaceable cartridge for receiving the aerosol-forming substance, the replaceable cartridge being connectable to the housing. The control unit is configured to prevent charging of the battery, when the initiation of the electric heater is detected.

A filtration system having: (a) a recirculation loop, (b) a pump, (c) a waste outlet, (d) a valve separating the loop from a waste outlet (d) a control device for said valve, (e) a membrane pressure vessel comprising a feed port, concentrate port and permeate port, and hyperfiltration elements in an axial direction, including an end hyperfiltration element nearest an inlet port or outlet port, (f) a flow distributor located between said end hyperfiltration element and said fluid port to provide a velocity profile with a coefficient of variation of less than 0.1 or a flow resistance of between 10 and 200 kPase·cW·<-1>, (g) wherein the flow distributor has a proximal surface nearest the end hyperfiltration element and a distal surface nearest said fluid port, and (h) an axial positioner that locates said distal surface at least 50% of the distance between the end hyperfiltration element and the port.

This application provides azeotropic and near-azeotropic compositions of Z-1,1,1,4,4,4-hexafluorobut-2-ene (Z-HFO-1336mzz) and a second component selected from the group consisting of n-butane and isobutane. The inventive compositions are useful as aerosol propellants, refrigerants, cleaning agents, expansion agents for thermoplastic and thermoset foams, solvents, heat transfer media, power cycle working fluids, polymerization media, particulate removal fluids, carrier fluids, buffing abrasive agents, and displacement drying agents.

A method of making chlorofluorohydrocarbons including, contacting, a fluorinated hydrocarbon reagent in the vapor phase, with hydrogen chloride (HCl). The reaction is conducted in the presence of an effective amount of a catalyst, at an elevated temperature sufficient to effect hydrochlorination to form a reaction mixture including a chlorofluorohydrocarbon.

A method for extinguishing a flame and terminating thermal runaway in a device powered by a lithium ion battery. The disclosure also provides a system for extinguishing fires generated by lithium ion batteries exhibiting thermal runaway.

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