Vorrichtung und Verfahren zur Ausführung einer digitalen PCR

EP2878374 Art B1 12. Mai 2021

Anmelder: IMEC VZW 🇧🇪

Details

Veröffentlichungs-Nr.
EP2878374
Aktenzeichen
EP13195075
Anmeldetag
29. November 2013
Veröffentlichung
12. Mai 2021
Erteilung
12. Mai 2021
Rechtsraum
EP
IPC
B01L3/00B01L7/00
Offizieller Volltext

Abstract

A micro-fluidic device 100 for performing digital PCR is presented. The device comprises: a semiconductor substrate; a first micro-fluidic channel 104, comprising an inlet 102 and an outlet 103, embedded in the semiconductor substrate; a heating element 101 thermally coupled to the first micro-fluidic channel 104; a droplet generator 107 connected to the inlet 102 of the first micro-fluidic channel 104 for generating droplets and pumping generated droplets at a flow rate into the first micro-fluidic channel 104; characterized in that: the heating element 101 is a single heating element connected to a temperature control unit 111 configured to cycle the temperature of the complete first micro-fluidic channel 104 through at least two temperature values; and wherein the flow rate of the droplet generator 107 is adaptable. Further, a method to perform digital PCR is presented using the micro-fluidic device 100.

Anmelder

Firma
IMEC VZW
Land
🇧🇪 Belgien
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