Verfahren zur Flüssigchromatographischen Massenspektrometrie und Flüssigchromatographmassenspektrometer

Details

Veröffentlichungs-Nr.

EP3401945

Aktenzeichen

EP18170686

Anmeldetag

3. Mai 2018

Veröffentlichung

6. August 2025

Erteilung

6. August 2025

Rechtsraum

EP

IPC

H01J49/16H01J49/04

Abstract

In an LC/MS analysis of a sample containing various compounds, additive supply pumps 164A and 164B in a post-column adding unit 16 draw and supply different kinds of additives A and B from containers 163A and 163B, respectively. The additives are mixed into an eluate through T-joints 162 and 161. A preferable combination of the additives is the combination of DMSO which produces the effect of gathering charge states and 2-propanol which produces the effect of promoting atomization or vaporization of droplets. By mixing the two additives into the eluate while mixing them at an appropriate flow-rate ratio according to a previously determined flow-rate program, the ionization efficiency can be nearly optimized for each compound during the process of generating ions by spraying electrically charged droplets of the eluate from an ESI spray 21. Consequently, the detection sensitivity becomes higher than conventional levels.

Anmelder

Firma

Shimadzu Corporation

Land

🇯🇵 Japan

Fachgebiete